- March 19, 2024Source: American Heart Association
Study offers insight on how hot weather impairs the immune system
- March 11, 2024Source: Yale Medicine
Why Your Cardiologist May Prescribe Semaglutide (Wegovy)
- February 05, 2024Source: CNN
‘It’s a new era’: Weight-loss treatments significantly lower blood pressure, studies finds
- October 03, 2023Source: The Washington Post
An epidemic of chronic illness is killing us too soon
Heart Disease and Stroke
Heart Disease and Stroke are leading causes of death and disability in the United States and worldwide. Numerous primary and secondary faculty used rigorous epidemiologic methods to improve our understanding of heart disease and stroke conducting research both nationally and internationally. For example, in the Department of Chronic Disease Epidemiology, the availability of access to large administrative medical claims databases enables researchers to investigate long term trends, patterns of care, and outcomes among elderly patients with heart disease and stroke.
Our research areas include:
- disease trends
- the role of traditional risk factors
- genetics
- biomarkers
- patterns of care
- biological, social, and environmental factors that influence the presentation and outcomes of young women with heart disease
- effect of community-based characteristics on disease rates and outcomes.
Recent Publications
2024
- An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH).Zhu Z, Bo-Ran Ho B, Chen A, Amrhein J, Apetrei A, Carpenter TO, Lazaretti-Castro M, Colazo JM, McCrystal Dahir K, Geßner M, Gurevich E, Heier CA, Simmons JH, Hunley TE, Hoppe B, Jacobsen C, Kouri A, Ma N, Majumdar S, Molin A, Nokoff N, Ott SM, Peña HG, Santos F, Tebben P, Topor LS, Deng Y, Bergwitz C. Kidney Int. 2024 May; 2024 Feb 15. PMID: 38364990.
- DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality.Liang X, Aouizerat BE, So-Armah K, Cohen MH, Marconi VC, Xu K, Justice AC. Aging Cell. 2024 Apr 17; 2024 Apr 17. PMID: 38629454.
- Acute Cardiac Events in Hospitalized Older Adults With Respiratory Syncytial Virus Infection.Woodruff RC, Melgar M, Pham H, Sperling LS, Loustalot F, Kirley PD, Austin E, Yousey-Hindes K, Openo KP, Ryan P, Brown C, Lynfield R, Davis SS, Barney G, Tesini B, Sutton M, Talbot HK, Zahid H, Kim L, Havers FP. JAMA Intern Med. 2024 Apr 15; 2024 Apr 15. PMID: 38619857.
- IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease.Serrano IM, Ribeiro G, Santos RS, Cruz JS, Lanza FC, Santos EFD, Almeida MC, Soares JFS, Luquetti AO, Celedon PAF, Zanchin NIT, Santos FLN, Reis MGD. Am J Trop Med Hyg. 2024 Apr 3; 2024 Feb 27. PMID: 38412539.
- Biometric contrastive learning for data-efficient deep learning from electrocardiographic images.Sangha V, Khunte A, Holste G, Mortazavi BJ, Wang Z, Oikonomou EK, Khera R. J Am Med Inform Assoc. 2024 Apr 3. PMID: 38269618.
- Study Protocol for the Artificial Intelligence-Driven Evaluation of Structural Heart Diseases Using Wearable Electrocardiogram (ID-SHD).Aminorroaya A, Dhingra LS, Camargos AP, Shankar SV, Khunte A, Sangha V, McNamara RL, Haynes N, Oikonomou EK, Khera R. medRxiv. 2024 Mar 19; 2024 Mar 19. PMID: 38562867.
- Statistical methods for assessing the effects of de novo variants on birth defects.Xie Y, Wu R, Li H, Dong W, Zhou G, Zhao H. Hum Genomics. 2024 Mar 14; 2024 Mar 14. PMID: 38486307.
- CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut.Peng S, Li JJ, Song W, Li Y, Zeng L, Liang Q, Wen X, Shang H, Liu K, Peng P, Xue W, Zou B, Yang L, Liang J, Zhang Z, Guo S, Chen T, Li W, Jin M, Xing XB, Wan P, Liu C, Lin H, Wei H, Lee RWJ, Zhang F, Wei L. Cell. 2024 Mar 14; 2024 Feb 26. PMID: 38412859.
- Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts.Zhang X, Hu Y, Vandenhoudt RE, Yan C, Marconi VC, Cohen MH, Wang Z, Justice AC, Aouizerat BE, Xu K. PLoS Pathog. 2024 Mar; 2024 Mar 11. PMID: 38466776.
- Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia.Abelman RA, Fitzpatrick J, Byanova KL, Zawedde J, Sanyu I, Byanyima P, Musisi E, Hsieh J, Zhang M, Branchini J, Sessolo A, Hunt PW, Lalitha R, Davis JL, Crothers K, Worodria W, Huang L. Open Forum Infect Dis. 2024 Mar; 2024 Jan 22. PMID: 38456193.
- Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan.Gaffey AE, Spatz ES. Curr Atheroscler Rep. 2024 Mar; 2024 Jan 19. PMID: 38240928.
- The role of viral interference in shaping RSV epidemics following the 2009 H1N1 influenza pandemic.Li K, Thindwa D, Weinberger DM, Pitzer VE. medRxiv. 2024 Feb 27; 2024 Feb 27. PMID: 38464193.
- Long-term exposure to wildfire smoke PM(2.5) and mortality in the contiguous United States.Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz HM, Bell ML, Chen K. medRxiv. 2024 Feb 26; 2024 Feb 26. PMID: 36778437.
- Enduring Injustice: Infectious Disease Outbreaks in Carceral Settings.Andrews JR, Liu YE, Croda J. J Infect Dis. 2024 Feb 14. PMID: 37493282.
- Contribution of climate change to the spatial expansion of West Nile virus in Europe.Erazo D, Grant L, Ghisbain G, Marini G, Colón-González FJ, Wint W, Rizzoli A, Van Bortel W, Vogels CBF, Grubaugh ND, Mengel M, Frieler K, Thiery W, Dellicour S. Nat Commun. 2024 Feb 8; 2024 Feb 8. PMID: 38331945.
- Assessing heterogeneity of patient and health system delay among TB in a population with internal migrants in China.Sun R, Wu Z, Zhang H, Huang J, Liu Y, Chen M, Lv Y, Zhao F, Zhang Y, Li M, Yan J, Jiang H, Zhan Y, Xu J, Xu Y, Yuan J, Zhao Y, Shen X, Yang C. Front Public Health. 2024; 2024 Feb 2. PMID: 38371243.
- Modelling counterfactual incidence during the transition towards culture-independent diagnostic testing.Healy JM, Ray L, Tack DM, Eikmeier D, Tobin-D'Angelo M, Wilson E, Hurd S, Lathrop S, McGuire SM, Bruce BB. Int J Epidemiol. 2024 Feb 1. PMID: 37820050.
- When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review.Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B. J Am Coll Cardiol. 2024 Jan 23. PMID: 38233019.
- High prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana.Ayanful-Torgby R, Shabanova V, Essuman AA, Boafo E, Aboagye F, Al-Mahroof Y, Amponsah J, Tetteh JKA, Amoah LE, Paintsil E. HIV Med. 2024 Jan 19; 2024 Jan 19. PMID: 38240173.
- Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.Torres-Bustamante M, Cantillo-Barraza O, Ko AI, Wunder EA, Quintero-Vélez JC. Res Sq. 2024 Jan 4; 2024 Jan 4. PMID: 38260656.
- Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency.Little JS, Oakley MS, Thorner AR, Johnston D, Majam V, Liakos AD, Novack LA, Zheng H, Meredith S, Chou CK, Newton BR, Soiffer RJ, Krause PJ, Baden LR, Kumar S. Open Forum Infect Dis. 2024 Jan; 2023 Nov 13. PMID: 38213635.
2023
- Typhoid fever.Meiring JE, Khanam F, Basnyat B, Charles RC, Crump JA, Debellut F, Holt KE, Kariuki S, Mugisha E, Neuzil KM, Parry CM, Pitzer VE, Pollard AJ, Qadri F, Gordon MA. Nat Rev Dis Primers. 2023 Dec 14; 2023 Dec 14. PMID: 38097589.
- The population-level impact of Enterococcus faecalis genetics on intestinal colonization and extraintestinal infection.Chaguza C, Pöntinen AK, Top J, Arredondo-Alonso S, Freitas AR, Novais C, Torres C, Bentley SD, Peixe L, Coque TM, Willems RJL, Corander J. Microbiol Spectr. 2023 Dec 12; 2023 Oct 9. PMID: 37811975.
- Self-care and healthcare seeking practices among patients with hypertension and diabetes in rural Uganda.Tusubira AK, Ssinabulya I, Kalyesubula R, Nalwadda CK, Akiteng AR, Ngaruiya C, Rabin TL, Katahoire A, Armstrong-Hough M, Hsieh E, Hawley NL, Schwartz JI. PLOS Glob Public Health. 2023; 2023 Dec 11. PMID: 38079386.
- Leptospirosis seroprevalence and risk factors among slaughterhouse workers in Burkina Faso.Zida S, Ouédraogo HG, Compaoré TR, Sagna T, Soubeiga ST, Banhoro BY, Zouré AA, Kambiré D, Dicko A, Wunder EA Jr, Kouanda S. IJID Reg. 2023 Dec; 2023 Oct 30. PMID: 38074946.
Click here to download the full summary of YSPH 2023 research findings in publication.
for Faculty working in this area.
Centers and other resources
- Becoming Breastfeeding Friendly (BBF): A Guide to Global Scale UpThis evidence-informed initiative is designed to help countries identify the strength of their breastfeeding-friendly environment and to improve breastfeeding policies and programs.
- Center for Neuroepidemiology and Clinical Neurological Research (CNE2)CNE2 is comprised of researchers across Yale schools who have common and complementary research and methodological interests in clinical neurological research.
- Community Alliance for Research and Engagement (CARE)CARE promotes the prevention of chronic diseases by focusing on social, environmental, and behavioral risk factors.
- Samoan Obesity, lifestyle and Genetic Adaptations Study Group (OLAGA)OLAGA study group aims to understand the origins of obesity among Samoans and other Pacific Islanders to develop relevant interventions to reduce obesity and obesity-related conditions.
- Yale Cancer Center (YCC)The Center provides the best approaches for the prevention, detection, diagnosis, and treatment of cancer.
- Yale-Griffin Prevention Research Center (PRC)The PRC works with community partners to develop and implement community-based approaches to prevent and control chronic diseases such as heart disease, diabetes, and cancer.
- Yale Institute for Global Health (YIGH)YIGH serves as the focal point for research, education, and engagement with global partners to improve the health of individuals and populations worldwide.